GESTATIONAL PEMPHIGOID Gestacijski PEMPHIGOID

Gestational pemphigoid Gestacijski pemphigoid

Also known as: Također poznat kao:

•  Pemphigoid gestationis • Pemphigoid gestationis

•  Herpes gestationis • Herpes gestationis

SKIN BLISTER Podnošljivost za kožu BLISTER

Picture of a blister, which is the primary lesions in pemphigus-like disorders. Slika žulj, koja je primarna lezija u pemfigus poput poremećaja.

PREGNANCY AND POSTPARTUM SKIN Trudnoća i POSTPARTUM kože

Gestational pemphigoid is a benign skin condition that only occurs during pregnancy or immediately postpartum. Gestacijski pemphigoid je dobar kože stanju da događa samo za vrijeme trudnoće ili odmah postpartum. It is known to be associated with molar pregnancies and choriocarcinomas. Poznato je da je povezana s melje pregnancies i choriocarcinomas. The incidence of gestational pemphigoid is around 1:100,000. Pojave Gestacijski pemphigoid je oko 1:100000. Gestational pemphigoid presents late in pregnancy with an abrupt onset. Gestacijski pemphigoid predstavlja kasno u trudnoći s iznenadan napad.

AUTOIMMUNE MECHANISM Autoimune MEHANIZAM

Gestational pemphigoid is caused by anti-basement membrance antibodies that circulate in the blood initiated by pregnancy. Gestacijski pemphigoid je uzrokovana anti-podrum membrance antitijela koji cirkuliraju u krvi koju je pokrenuo trudnoće. These anti-basement membrane antibodies cause complement C3 deposition along the dermal-epidermal junction of the skin, resulting in the characteristic skin changes. Ti anti-podrumske izazvati membrana protutijela komplement C3 depozicije uz kožni-epidermalan spajanja na koži, što je rezultiralo u karakterističnim promjenama kože. There is also a high prevalence of circulating anti-HLA/MHC antibodies in these patients. Tu je i visoka prevalencija u opticaju anti-HLA/MHC protutijela u tih bolesnika. HLA antigens, HLA DR3 or HLA DR4 are found in nearly all these patients. HLA antigeni, HLA DR3 ili HLA DR4 nalaze u gotovo svim tim pacijentima. It is believed that gestational pemphigoid is initiated by the expression of MHC class II antigens of the paternal contribution to the placenta that serves as an initiating factor, that causes the formation of these anti-HLA antibodies that subsequently cross-react with similar HLA molecules found on the mothers skin. Pretpostavlja se da je Gestacijski pemphigoid je pokrenuo izraz HLA antigeni razreda II u očev doprinos placente koja služi kao pokretanje faktor, koji uzrokuje formiranje tih anti-HLA protutijela koja potom unakrsno reaguje sa sličnim HLA molekula pronađena o majkama kože.