GESTATIONAL PEMPHIGOID Gestacijsko PEMPHIGOID

Gestational pemphigoid Gestacijska pemphigoid

Also known as: Also known as:

•  Pemphigoid gestationis • Pemphigoid gestationis

•  Herpes gestationis • Herpes gestationis

SKIN BLISTER STIK S KOŽO DVOJNEM TRAKU

Picture of a blister, which is the primary lesions in pemphigus-like disorders. Slika pretisnem omotu, ki je primarni lezije v pemphigus podobne težave.

PREGNANCY AND POSTPARTUM SKIN Nosečnostjo in po porodu koža

Gestational pemphigoid is a benign skin condition that only occurs during pregnancy or immediately postpartum. Gestacijska pemphigoid, je benigna kožna pogojem, da se pojavi samo v času nosečnosti ali takoj po porodu. It is known to be associated with molar pregnancies and choriocarcinomas. Znano je, da so povezani z molsko nosečnosti in choriocarcinomas. The incidence of gestational pemphigoid is around 1:100,000. Incidenca gestacijsko pemphigoid je okoli 1:100000. Gestational pemphigoid presents late in pregnancy with an abrupt onset. Gestacijska pemphigoid predstavlja v pozni nosečnosti z nenadnim nastopom.

AUTOIMMUNE MECHANISM Avtoimunskih MEHANIZEM

Gestational pemphigoid is caused by anti-basement membrance antibodies that circulate in the blood initiated by pregnancy. Gestacijska pemphigoid je posledica anti-klet membrance protitelesa, ki krožijo v krvi, ki ga nosečnosti. These anti-basement membrane antibodies cause complement C3 deposition along the dermal-epidermal junction of the skin, resulting in the characteristic skin changes. Ti anti-klet membranskih protiteles povzroči dopolnjujejo C3 odlaganja vzdolž epidermalni dermalno-stičišča na koži, ki izhajajo iz značilne kožne spremembe. There is also a high prevalence of circulating anti-HLA/MHC antibodies in these patients. Obstaja tudi visoka prevalenca na krožeča anti-HLA/MHC protiteles pri teh bolnikih. HLA antigens, HLA DR3 or HLA DR4 are found in nearly all these patients. HLA antigeni HLA DR3 ali HLA DR4 se ugotovi, da so v skoraj vseh teh bolnikih. It is believed that gestational pemphigoid is initiated by the expression of MHC class II antigens of the paternal contribution to the placenta that serves as an initiating factor, that causes the formation of these anti-HLA antibodies that subsequently cross-react with similar HLA molecules found on the mothers skin. Menijo, da so gestacijsko pemphigoid se začne z izražanjem MHC razreda II antigenov iz starševske prispevek k placente, ki služi kot pobudnica dejavnik, ki povzroča nastanek teh protiteles anti-HLA, ki nato reagira navzkrižno s podobnimi HLA molekule ugotovljeno, o mater kože.